Search results for "Longitudinal data"
showing 10 items of 53 documents
Druggable genome and precision medicine in cancer: current challenges.
2021
The past decades have seen tremendous developments with respect to "specific" therapeutics that target key signaling molecules to conquer cancer. The key advancements with multiomics technologies, especially genomics, have allowed physicians and molecular oncologists to design "tailor-made" solutions to the specific oncogenes that are deregulated in individual patients, a strategy which has turned out to be successful though the patients quickly develop resistance. The swift integration of multidisciplinary approaches has led to the development of "next generation" therapeutics and, with synergistic therapeutic regimes combined with immune checkpoint inhibitors to reactivate the dampened im…
Participation and Performance Trends in Triple Iron Ultra-triathlon – a Cross-sectional and Longitudinal Data Analysis
2012
Purpose: The aims of the present study were to investigate (i) the changes in participation and performance and (ii) the gender difference in Triple Iron ultra-triathlon (11.4 km swimming, 540 km cycling and 126.6 km running) across years from 1988 to 2011. Methods: For the cross-sectional data analysis, the association between with overall race times and split times was investigated using simple linear regression analyses and analysis of variance. For the longitudinal data analysis, the changes in race times for the five men and women with the highest number of participations were analysed using simple linear regression analyses. Results: During the studied period, the number of finishers …
The age of peak performance in Ironman triathlon: a cross-sectional and longitudinal data analysis.
2013
Abstract Background The aims of the present study were, firstly, to investigate in a cross-sectional analysis the age of peak Ironman performance within one calendar year in all qualifiers for Ironman Hawaii and Ironman Hawaii; secondly, to determine in a longitudinal analysis on a qualifier for Ironman Hawaii whether the age of peak Ironman performance and Ironman performance itself change across years; and thirdly, to determine the gender difference in performance. Methods In a cross-sectional analysis, the age of the top ten finishers for all qualifier races for Ironman Hawaii and Ironman Hawaii was determined in 2010. For a longitudinal analysis, the age and the performance of the annua…
Declining Sexual Activity and Desire in Men—Findings From Representative German Surveys, 2005 and 2016
2017
Abstract Background Surveys have indicated an increase of sexual activity in aging men; recently, however, a decrease of sexual activity has been reported in young men. Aim To assess (i) sexual activity and desire and their determinants across the age range in a population-based male sample and (ii) their changes over 11 years. Methods A representative survey of men (N = 1,095) 18 to 93 years old from 2016 was compared with a survey from 2005 (N = 1,106 men) with the same age range. Samples were drawn from the German population at random using standardized sampling procedures. Questions were filled out by participants in the presence of a trained interviewer. Sexual activity was compared us…
The 9-item Bergen Burnout Inventory: Factorial Validity Across Organizations and Measurements of Longitudinal Data
2013
The present study tested the factorial validity of the 9-item Bergen Burnout Inventory (BBI-9) 1) . The BBI-9 is comprised of three core dimensions: (1) exhaustion at work; (2) cynicism toward the meaning of work; and (3) sense of inadequacy at work. The study further investigated whether the three-factor structure of the BBI-9 remains the same across different organizations (group invariance) and measurement time points (time invariance). The factorial group invariance was tested using a cross-sectional design with data pertaining to managers (n=742), and employees working in a bank (n=162), an engineering office (n=236), a public sector organization divided into three service areas: admin…
Adaptation to life after surgical removal of the bladder—an application of graphical Markov models for analysing longitudinal data
2004
Graphical Markov models have been developed particularly for the analysis of observational data. They allow the control of various background variables when analysing theoretically relevant associations. This paper demonstrates the application and some advantages of graphical Markov models in comparison to conventional statistical analyses. The aim of the study was to identify patients at risk for developing decreased health-related quality of life (QoL) after cystectomy and to explore the influence of coping on QoL in this situation. Therefore, the method was applied to analyse the data of a prospective study, in which 81 patients with bladder cancer were interviewed pre-operatively and in…
Do low burnout and high work engagement always go hand in hand? Investigation of the energy and identification dimensions in longitudinal data
2011
The aim of the present 2-year follow-up study among young managers (N=433) was to investigate the intraindividual developmental patterns of burnout and work engagement as well as their interconnections. More specifically, we examined the interconnectedness of the varying patterns (i.e., latent classes) of exhaustion and vigor (i.e., the energy dimension) and cynicism and dedication (i.e., the identification dimension) across time. The latent class solutions supported by the growth mixture modeling indicated four latent classes for exhaustion and five for vigor. In addition, four latent classes were found for cynicism and six for dedication. Cynicism and dedication represented opposites with…
Can personality predict retirement behaviour? A longitudinal analysis combining survey and register data from Norway.
2017
Published version of an article in the journal: European Journal of Ageing. Also available from the publisher at: http://dx.doi.org/10.1007/s10433-011-0212-6 This study investigates how far personality can predict the timing and routes of people’s retirement. It uses a large comprehensive Norwegian survey, with larger sample size than earlier related studies, providing estimates of personality based on the five-factor model. The survey data are matched with administrative data, allowing observations of retirement over the 2002–2007 period. The analysis distinguishes between the disability and the non-disability retirements. Retirement is investigated using discrete time, competing risk, log…
A statistical monitoring approach for automotive on-board diagnostic systems
2007
The current generation of vehicle models are increasingly being equipped with on-board diagnostic (OBD) systems aimed at assessing the ‘state of health’ of important anti-pollution subsystems and components. In order to promptly diagnose and fix quality and reliability problems that may potentially affect such complex diagnostic systems, even during advanced development prior to mass production, some vehicle prototypes undergo a testing phase under realistic conditions of use (a mileage accumulation campaign). The aim of this work is to set up a statistical tool for improving the reliability of the OBD system by monitoring its operation during the mileage accumulation campaign of a new vehi…
PENDEKATAN ANALISIS REGRESI INDIVIDUAL UNTUK DATA LONGITUDINAL
2008
<p><em>Classical Regression analysis are usually used in analysing longitude data or repeated measurement data (where response from each individual were measured in a period of time). Assumption of the analysis is no correlation among a couple measurement at same object. Whereas the repeated measurement data in same object research usually have correlation. Neglecting of correlation in regresion analysis will result in an uncertain conclusion.Regression individually analysis for longitudinal data attention the influence of individual effect and its interaction with time. So that with the reason, withdrawal of conclusion will be more be trusted its truth.The research objective i…